Young Red Haired Girl Posing On The Floor At Home

Biochemistry and genetics
The pigment pheomelanin gives red hair its distinctive color. Red hair has far more of the pigment pheomelanin than it has of the dark pigment eumelanin.
The genetics of red hair, discovered in 1997, appear to be associated with the melanocortin-1 receptor (MC1R), which is found on chromosome 16. Red hair is associated with fair skin color due to low concentrations of eumelanin throughout the body of those with red hair. This lower melanin-concentration confers the advantage that a sufficient concentration of important Vitamin D can be produced under low light conditions. However, when UV-radiation is strong (like in regions close to the equator) the lower concentration of melanin leads to several medical disadvantages, such as a higher risk of skin cancer.
The MC1R recessive variant gene that gives people red hair and fair skin is also associated with freckles, though it is not uncommon to see a redhead without freckles. Eighty percent of redheads have an MC1R gene variant, and the prevalence of these alleles is highest in Scotland and Ireland. The alleles that code for red hair occur close to the alleles that affect skin color, so it seems that the phenotypic expression for lighter skin and red hair are interrelated.